In this work, fourteen synthetic routes of vinyl chloride are generated from ‘create-reactionset’ software that runs on MATLAB using the molar constraints of all the molecules of the reactants, products and the by-products involved in the manufacture of one unit of vinyl chloride. In order to quantitatively evaluate the energy performance and the potential profits of the process routes, comparison of the fourteen synthetic routes showed that eight synthetic routes is heat absorbing reactions requiring energy input, while six are heat generating reactions resulting to negative energy quality. Route, with synthetic reaction Cl2+HCl+O2 + C2H4-->2H2O + 3C2H3Cl, and with exergy dissipation of -1370.1563Kcal/g-mol and a potential profit of 51c/lb is considered as being sustainable. The comparison rendered it possible to rapidly screen out synthetic routes that are highly unlikely to be sustainable at the earliest possible stage thereby preventing the enormous expenditure required for developing such processes. Definitions and calculation formulas of exergy and potential profits of a substance, a mixture, a stream, and a unit (process) are illustrated.