Hundreds of thousands of people throughout the world suffer from sickle cell disease (SCD), a widely prevalent genetic hematological condition. Osteomyelitis is most often caused by Staphylococcus aureus. Although it can be hard to tell the difference between benign SCD disorders and osteomyelitis, the latter is a dangerous and ultimately incapacitating illness. A thorough assessment of the clinical presentation, laboratory findings, and imaging is necessary for the diagnosis of osteomyelitis. Individuals with SCD may get medicinal or surgical therapies for osteomyelitis; however, in order to achieve the best results, care must be exercised in the preoperative and postoperative choice of antibiotics and maintenance.